Study: IVF- miscarriage linked to age and embryo type

A recent study reveals that a woman’s age and the type of embryo(s) used affect the outcome of IVF procedures.

The retrospective analysis of 52,874 pregnancies recorded on the Australian and New Zealand Assisted Reproduction Database (ANZARD) showed that women younger than 35 years old are almost 3 times less likely to miscarry compared with women over the age of 40. Miscarriage is also less likely to occur after the transfer of fresh embryos compared with frozen-thawed embryos.

Women who had a single embryo transfer were less likely to miscarry than if two embryos were transferred. Also, transferring thawed embryos which were frozen at an earlier stage of development than the blastocyst were less likely to miscarry.

“It is interesting that miscarriage rates of frozen blastocysts were higher in the Australian study, particularly since it is well known that blastocysts have a lower frequency of chromosomal anomalies than cleaved embryos. Blastocyst culture is still a relatively new approach and culture-related factors such as selection for freezing at blastocyst stage may have affected early learning experiences in some clinics. It is therefore important to repeat a similar analysis of Australian clinic data during subsequent years,” remarks Dr. Jacques Cohen, senior editor of Reproductive BioMedicine Online.

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SOURCE: Reproductive BioMedicine Online, Vol. 23, Issue 6, Pages 777-788.

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